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KMID : 1011420160210040333
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Journal of Korean Ophthalmic Optics Society
2016 Volume.21 No. 4 p.333 ~ p.340
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Antibacterial Activity of Quercetin and trans-Chalcone for Application in Contact Lens Multipurpose Solution
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Choi Ji-Young
Kang Jong-Seok
Han Jong-Gil
Byun Jong-Chul
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Abstract
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Purpose: We investigated antibacterial activities of quercetin and trans-chalcone against contact lens-related bacteria and evaluated their potential as disinfectant in contact lens multipurpose solution(MPS).
Methods: Antibacterial activities of quercetin and trans-chalcone, which are flavonoids, against Staphyloccus aereus and Pseudomonas aeruginosa were determined. After trans-chalcone treatment in MPS with weak antibacterial activity, its growth inhibition effect to bacteria was also determined.
Results: Both of quercetin and trans-chalcone showed antibacterial activity against S. aereus, but did not show against P. aeruginosa. As the results of MIC against S. aereus, trans-chalcone showed higher activity than quercetin (quercetin: IC90 149 ㎍/ml, IC50 31.0 ㎍/ml trans-chalcone: IC90 15.2 ㎍/ml, IC50 8.9 ㎍/ml). In the antibacterial activities experiment of MPSs, MPS of F Company showed a low activity against both S. aereus and P. aeruginosa. The antibacterial activity of the F company’s MPS was investigated by adding trans-chalcone. As a result, the antibacterial activity was exhibited from 75% concentration of IC90(11.4 ㎍/ml).
Conclusions: Quercetin and transchalcone, which are flavonoids, showed antibacterial activities against S. aereus and trans-chalcone had higher activity. Hence, this result suggests that quercetin and trans-chalcone can be applied to a disinfectant of MPS.
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KEYWORD
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Quercetin, trans-Chalcone, Flavonoid, Multipurpose solution(MPS), Antibacterial activity
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